LRRTM1 leucine rich repeat transmembrane neuronal 1 [ (human)]. Gene ID: , updated on 7-Dec This gene is imprinted, being predominantly expressed from the paternal allele and showing a variable pattern of maternal down-regulation. May be associated . Leucine-rich repeat transmembrane neuronal protein 1. Gene. Lrrtm1. Organism. Mus musculus (Mouse). Status. Reviewed-Annotation score: Annotation.
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These are stable identifiers and should be used to cite UniProtKB entries. The final SNP map that we used in this region is shown see also Table S1and the three SNPs that showed the initial paternal-specific haplotype associations are highlighted by pink circles rsrsrs These results suggest that endogenous LRRTM1 may have a role in intracellular trafficking within axons.
Genevisible search portal to normalized and curated expression data from Genevestigator More Q86UE6 Primary citable accession number: LRRTM1 aids in the assembly of complex retinogenciulate synapses in mice, which are believed to help process complex visual signals.
RCSB PDB – Gene View – LRRTM1 – leucine rich repeat transmembrane neuronal 1
Our website will not work properly. This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.
View this region in JBrowse. This entry has 1 described isoform and 1 potential isoform that is computationally mapped.
Supplementary Table S1 genr Information doc K. R-MMU Neurexins and neuroligins. June 21, Last sequence update: UniGene gene-oriented nucleotide sequence clusters More See Using the Quick Search Tool for more information.
H-Invitational Database, human transcriptome db More Epigenetic silencing of PEG3 gene expression in human glioma cell lines.
Click on grid cells to view annotations. Search for genome features by name, symbol, synonym, homolog, allele, or gee ID: Discussion Crow proposed that handedness, brain asymmetry and schizophrenia share an underlying genetic relationship. Leucine-rich repeat transmembrane neuronal protein 1.
However, it is also possible that the failure to replicate the association with handedness was due to low power and a relatively small replication sample in our study.
LRRTM1 – leucine rich repeat transmembrane neuronal 1
Initially detected at 9 dpc with expression present in the overlying ectoderm of the limb bud in the presumptive apical ectodermal ridge. Expression of Lrrtm1 was detected in cerebral cortex, cerebellum and brain stem, but it was biallelic Figure S5. Abnormalities of cerebral asymmetry are associated with schizophrenia and other neuropsychiatric disorders. Neurons but not glial cells show reciprocal imprinting of sense and antisense transcripts of Ube3a.
OMIM Entry – * – LEUCINE-RICH REPEAT TRANSMEMBRANE PROTEIN 1: LRRTM1
LRRTM1 is the first genetic influence on human handedness to be identified. TreeFam database of animal gene trees More Footnotes Supplementary Information accompanies the paper on the Molecular Psychiatry website http: We screened the first two exons and predicted promoter of LRRTM1 for polymorphisms in 26 left-handers from the RD sample by denaturing high-performance liquid chromatography and sequencing, but we did not detect any polymorphisms that tagged rsrsrs haplotypeor that had overt disruptive effects on the predicted LRRTM1 protein entirely coded within exon 2.
Genes on human chromosome 2 Motor skills Protein stubs. Protein interaction database and analysis system More From Wikipedia, the free encyclopedia. Introduction Left—right asymmetrical function is a conserved feature of vertebrate central nervous systems. May be associated paternally with handedness and schizophrenia. Mice homozygous for a knock-out allele exhibit impaired cognitive function and altered hippocampal synapse morphology. MGI integral component of membrane Source: Please update to a newer version or download a new web browser, such as Chrome or Firefox.
Genomewide scan in families with schizophrenia from the founder population of Afrikaners reveals evidence for linkage and uniparental disomy on chromosome 1. See other articles in PMC that cite the published article. BioMuta curated single-nucleotide variation and disease association database More Ensembl growth cone Source: Molecular Function carbohydrate derivative binding cytoskeletal protein binding DNA binding enzyme regulator hydrolase ligase lipid vene oxidoreductase RNA binding signaling receptor activity signaling receptor binding transcription transferase transporter.
A stripe of expression can be detected in lrrtmm1 neural tube.
Leucine-rich repeat transmembrane n A genome-wide scan for linkage to chromosomal regions in sibling pairs with schizophrenia or schizoaffective disorder. Supplementary Figure S2 jpeg 37K Click here to view. More caudal still c lgrtm1, thalamic signal shifts ventrally to a structure consistent with the lateral geniculate body.